Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice

Abstract excerpt

Significance Non-Hodgkin lymphomas are associated with HIV infection. Current hypotheses on lymphomagenesis, based on immunosuppression and/or activation and/or inflammation, are generic and do not provide mechanistic, testable models. Here we show that several HIV proteins are expressed in a HIV transgenic mouse model of lymphoma, but only Matrix/p17 is consistently expressed at high levels even in early disease...

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