Article
Risk factors for breast cancer characterized by the estrogen receptor alpha A908G (K303R) mutation.
Breast cancer research : BCR - 1 Jan 2007
Conway Kathleen, Parrish Eloise, Edmiston Sharon N, Tolbert Dawn, Tse Chiu-Kit, Moorman Patricia, Newman Beth, Millikan Robert C
Abstract excerpt
INTRODUCTION: Estrogen is important in the development of breast cancer, and its biological effects are mediated primarily through the two estrogen receptors alpha and beta. A point mutation in the estrogen receptor alpha gene, ESR1, referred to as A908G or K303R, was originally identified in breast hyperplasias and was reported to be hypersensitive to estrogen. We recently detected this mutation at a low...
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