Article
Association of HSD3B1 Genotype and Clinical Outcomes in Postmenopausal Estrogen-Receptor-Positive Breast Cancer.
Annals of surgical oncology - 1 Oct 2022
Flanagan Meghan R, Doody David R, Voutsinas Jenna, Wu Qian, Banda Kalyan, Sharifi Nima, Li Christopher I, Gadi Vijayakrishna K
Abstract excerpt
BACKGROUND: Homozygous inheritance of a single-nucleotide polymorphism (1245A > C) in HSD3B1 results in an adrenal permissive phenotype of increased adrenal steroid precursor conversion to potent androgens. This is associated with poor outcomes in prostate cancer. We hypothesized that inheritance of the HSD3B1 adrenal permissive genotype would similarly negatively impact breast cancer outcomes. PATIENTS AND...
Topics
Join the communities discussing this publication.