Article
Estrogen receptor alpha mutation (A-to-G transition at nucleotide 908) is not found in different types of breast lesions from Japanese women.
Breast cancer (Tokyo, Japan) - 1 Jan 2003
Zhang Zhenhuan, Yamashita Hiroko, Toyama Tatsuya, Omoto Yoko, Sugiura Hiroshi, Hara Yasuo, Haruki Nobuhiro, Kobayashi Shunzo, Iwase Hirotaka
Abstract excerpt
BACKGROUND: An estrogen receptor (ER) alpha variant with an A-to-G transition at nucleotide 908 (A908G) has been identified in typical hyperplastic mammary epithelium. This somatic mutation, which induces a Lys-to-Arg substitution at residue 303 within exon 4 at the border of the hinge and hormone-binding domains of the ER alpha, shows increased sensitivity to estrogen compared with wild-type ER alpha. METHODS:...
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