Article
Identification of Crucial Amino Acid Residues Involved in Agonist Signaling at the GPR55 Receptor.
Biochemistry - 24 Jan 2017
Lingerfelt Mary A, Zhao Pingwei, Sharir Haleli P, Hurst Dow P, Reggio Patricia H, Abood Mary E
Abstract excerpt
GPR55 is a newly deorphanized class A G-protein-coupled receptor that has been implicated in inflammatory pain, neuropathic pain, metabolic disorder, bone development, and cancer. Few potent GPR55 ligands have been identified to date. This is largely due to an absence of information about salient features of GPR55, such as residues important for signaling and residues implicated in the GPR55 signaling cascade....
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