Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nt mutation causing laterality defects associated with deletion of rotatin.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2007

Chatterjee Bishwanath, Richards Katharina, Bucan Maja, Lo Cecilia

Abstract excerpt

No turning (nt), a recessive lethal mutation causing left-right and axial patterning defects, was recovered in outbred CD-1 mice. Homozygous mutant embryos die at E11.5, exhibiting randomized heart tube looping and a failure to undergo embryonic turning. Previous studies showed notochordal defects associated with abnormal expression of HNF3beta, lefty, and nodal. To identify the genetic alteration underlying nt...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to Gene Deletion

Share to Gene Expression Regulation, Developmental

Share to Genes, Lethal

Share to Membrane Proteins

Share to Microsatellite Repeats

Source

Identifiers

PMID: 17551791
DOI: 10.1007/s00335-007-9023-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nt mutation causing laterality defects associated with deletion of rotatin.PMID 17551791Read ↗

No turning, a mouse mutation causing left-right and axial patterning defects.Semantic proximity Read ↗

Rotatin is a novel gene required for axial rotation and left-right specification in mouse embryos.Semantic proximity Read ↗

Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo.Semantic proximity Read ↗

Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.Semantic proximity Read ↗

Characterization and mutation analysis of human LEFTY A and LEFTY B, homologues of murine genes implicated in left-right axis development.Semantic proximity Read ↗

The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.Semantic proximity Read ↗

Rare copy number variations in congenital heart disease patients identify unique genes in left-right patterning.Semantic proximity Read ↗

The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination.Semantic proximity Read ↗

Loss of the ciliary kinase Nek8 causes left-right asymmetry defects.Semantic proximity Read ↗

Relationship between asymmetric nodal expression and the direction of embryonic turning.Semantic proximity Read ↗

Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus.Semantic proximity Read ↗

Mutations affecting growth cone guidance in Drosophila: genes necessary for guidance toward or away from the midline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.