Article
Variants of HSD11B2 gene in hypertensive disorders of pregnancy.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians - 1 Jun 2017
Kosicka Katarzyna, Siemiątkowska Anna, Pękal Agnieszka, Majchrzak-Celińska Aleksandra, Bręborowicz Grzegorz, Krzyścin Mariola, Główka Franciszek
Abstract excerpt
INTRODUCTION: One of the hypotheses concerning the etiology of gestational hypertension (GH) and pre-eclampsia (PE) assumes that they develop as a result of placenta malfunctioning at the early stage of pregnancy. Placental dysfunction is also associated with the decreased activity of 11β-hydroxysteroid dehydrogenase 2 (11β-HSD2), which in normal pregnancy protects the fetus from the excess of maternal cortisol....
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