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Article

Role of HSD11B2 polymorphisms in essential hypertension and the diuretic response to thiazides.

Kidney international - 1 Feb 2005

Williams Tracy A, Mulatero Paolo, Filigheddu Fabiana, Troffa Chiara, Milan Alberto, Argiolas Giuseppe, Parpaglia Paolo Pinna, Veglio Franco, Glorioso Nicola

Abstract excerpt

BACKGROUND: The renal 11beta-hydroxysteroid dehydrogenase type 2 (11beta HSD2) enzyme inactivates 11-hydroxy steroids in the kidney, thereby protecting the nonselective mineralocorticoid (MR) receptor from occupation by glucocorticoids. Loss-of-function mutations in the gene encoding 11beta HSD2 (HSD11B2) result in overstimulation of the MR and cause salt-sensitive hypertension. METHODS: We have investigated the...

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Identifiers

PMID: 15673310
DOI: 10.1111/j.1523-1755.2005.67119.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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