Article
Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels.
Endocrinology - 1 Jan 2010
Malavasi Elise L V, Kelly Val, Nath Nikita, Gambineri Alessandra, Dakin Rachel S, Pagotto Uberto, Pasquali Renato, Walker Brian R, Chapman Karen E
Abstract excerpt
Regeneration of active glucocorticoids within liver and adipose tissue by the enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) may be of pathophysiological importance in obesity and metabolic syndrome and is a therapeutic target in type 2 diabetes. Polymorphisms in HSD11B1, the g...
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