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Glucocorticoid synthesis-related genes: HSD11B1 and HSD11B2 in hypertensive disorders in pregnancy.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Jul 2013

Shimodaira Masanori, Nakayama Tomohiro, Sato Ichiro, Sato Naoyuki, Izawa Noriko, Mizutani Yoshihiro, Furuya Kiyohide, Yamamoto Tatsuo

Abstract excerpt

OBJECTIVE: To determine whether polymorphisms of the maternal glucocorticoid-related genes (HSD11B1 and HSD11B2) are associated with pregnancy-induced hypertension (PIH) in a haplotype-based case-control study. METHODS: A total of 166 PIH patients and 222 age-matched controls were genotyped, with two single-nucleotide polymorphisms (SNPs) for the HSD11B1 gene (rs2235543 and rs846910) and three SNPs for the...

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PMID: 23659736
DOI: 10.3109/09513590.2013.788623

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