Article
Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension.
American journal of hypertension - 1 Aug 2005
Mariniello Barbara, Ronconi Vanessa, Sardu Cipriana, Pagliericcio Antonella, Galletti Ferruccio, Strazzullo Pasquale, Palermo Mario, Boscaro Marco, Stewart Paul M, Mantero Franco, Giacchetti Gilberta
Abstract excerpt
BACKGROUND: The HSD11B2 gene, encoding the kidney isoenzyme 11beta-hydroxysteroid dehydrogenase, is a candidate for essential hypertension. We previously showed that the frequency of shorter alleles of a CA repeat polymorphism in the first intron of 11beta-HSD2 gene was significantly higher among salt-sensitive than salt-resistant individuals with hypertension. The aim of the study was to analyze the HSD11B2 gene...
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