Article
11β-hydroxysteroid dehydrogenase type 2 polymorphisms and activity in a Chilean essential hypertensive and normotensive cohort.
American journal of hypertension - 1 May 2012
Campino Carmen, Quinteros Hector, Owen Gareth I, Carvajal Cristian A, Morales Mauricio, Olivieri Oliviero, Guidi Giancesare, Faccini Giovanni, Pasini Francesco, Baudrand Rene, Padilla Oslando, Valdivia Carolina, Thichauer Juan, Lagos Carlos F, Kalergis Alexis M, Fardella Carlos E
Abstract excerpt
BACKGROUND: 11β-hydroxysteroid dehydrogenase type 2 enzyme (11β-HSD2) inactivates cortisol (F) to cortisone (E); its impairment is associated with hypertension. We reported that 15.7% of the Chilean essential hypertensives possessed a high F/E ratio suggesting a partial deficit in 11β-HSD2 activity. It has been reported that the G534A(Glu178/Glu) polymorphism in the HSD11B2 gene is associated with hypertension....
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