Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.

doi:10.1172/JCI27095

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Article

Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice.

The Journal of clinical investigation - 1 Jun 2007

Aihara Ken-ichi, Azuma Hiroyuki, Akaike Masashi, Ikeda Yasumasa, Sata Masataka, Takamori Nobuyuki, Yagi Shusuke, Iwase Takashi, Sumitomo Yuka, Kawano Hirotaka, Yamada Takashi, Fukuda Toru, Matsumoto Takahiro, Sekine Keisuke, Sato Takashi, Nakamichi Yuko, Yamamoto Yoko, Yoshimura Kimihiro, Watanabe Tomoyuki, Nakamura Takashi, Oomizu Akimasa, Tsukada Minoru, Hayashi Hideki, Sudo Toshiki, Kato Shigeaki, Matsumoto Toshio

Abstract excerpt

Heparin cofactor II (HCII) specifically inhibits thrombin action at sites of injured arterial wall, and patients with HCII deficiency exhibit advanced atherosclerosis. However, the in vivo effects and the molecular mechanism underlying the action of HCII during vascular remodeling remain elusive. To clarify the role of HCII in vascular remodeling, we generated HCII-deficient mice by gene targeting. In contrast to...

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PMID: 17549254
DOI: 10.1172/JCI27095
PMCID: PMC1878511

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