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Article

Factor XI-deficient mice exhibit increased bleeding after injury to the saphenous vein.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2017

Ay C, Hisada Y, Cooley B C, Mackman N

Abstract excerpt

Essentials Factor XI (FXI) deficient mice have normal hemostasis in a tail transection model. The hemostatic capacity of FXI-/- mice was assessed in three different bleeding models. FXI-/- mice have increased saphenous vein bleeding. FXI-/- mice may be a useful experimental model to study bleeding associated with FXI deficiency. SUMMARY: Background Factor XI (FXI) is a key component of the intrinsic pathway of...

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Identifiers

PMID: 28677246
DOI: 10.1111/jth.13766

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