Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.

doi:10.1158/1055-9965.EPI-06-0736

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Article

Associations between smoking, polymorphisms in polycyclic aromatic hydrocarbon (PAH) metabolism and conjugation genes and PAH-DNA adducts in prostate tumors differ by race.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2007

Nock Nora L, Tang Deliang, Rundle Andrew, Neslund-Dudas Christine, Savera Adnan T, Bock Cathryn H, Monaghan Kristin G, Koprowski Allison, Mitrache Nicoleta, Yang James J, Rybicki Benjamin A

Abstract excerpt

Polycyclic aromatic hydrocarbon (PAH)-DNA adducts may induce mutations that contribute to carcinogenesis. We evaluated potential associations between smoking and polymorphisms in PAH metabolism [CYP1A1 Ile 462Val, CYP1B1 Ala 119Ser and Leu 432Val, microsomal epoxide hydrolase (mEH) Tyr 113His and His139Arg, CYP3A4 A(-392)G] and conjugation [glutathione S-transferase (GST) M1 null deletion, GSTP1 Ile 105Val] genes...

Topics

Adenocarcinoma
Black or African American
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP1B1
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA Adducts

Epoxide Hydrolases

Glutathione S-Transferase pi

Glutathione Transferase

Humans

Immunohistochemistry

Male

Polycyclic Aromatic Hydrocarbons

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 17548691
DOI: 10.1158/1055-9965.EPI-06-0736
PMCID: PMC2151314

Genes

PAH
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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