Article
Comparison of polymorphisms in genes involved in polycyclic aromatic hydrocarbon metabolism with urinary phenanthrene metabolite ratios in smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2006
Hecht Stephen S, Carmella Steven G, Yoder Andrea, Chen Menglan, Li Zhong-ze, Le Chap, Dayton Rachel, Jensen Joni, Hatsukami Dorothy K
Abstract excerpt
The hypothesis that interindividual differences among smokers in the metabolism of polycyclic aromatic hydrocarbons (PAH) are related to lung cancer risk has been extensively investigated in the literature. These studies have compared lung cancer risk in groups of smokers with or without polymorphisms in genes involved in PAH metabolism. We believe that carcinogen metabolite phenotyping, involving the actual...
Topics
- Adolescent
- Adult
- Aged
- Analysis of Variance
- Aryl Hydrocarbon Hydroxylases
- Biomarkers, Tumor
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP1B1
- Epoxide Hydrolases