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Article

CYP1A2 polymorphisms, occupational and environmental exposures and risk of bladder cancer.

European journal of epidemiology - 1 Jul 2010

Pavanello Sofia, Mastrangelo Giuseppe, Placidi Donatella, Campagna Marcello, Pulliero Alessandra, Carta Angela, Arici Cecilia, Porru Stefano

Abstract excerpt

Cytochrome P4501A2 (CYP1A2) is a key enzyme for activation of bladder carcinogens. Polymorphisms in the 5'-noncoding promoter region of CYP1A2 gene [mainly -2467T/delT(rs35694136) and -163C/A(rs762551)], are crucial in modifying CYP1A2 activity in smokers. Within the framework of a hospital-based case/control study, we investigated the relationship between CYP1A2 polymorphisms, occupational/environmental...

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PMID: 20559687
DOI: 10.1007/s10654-010-9479-8

Genes

CYP1A2

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