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Article

Evaluation of NAD(+) -dependent DNA ligase of mycobacteria as a potential target for antibiotics.

Antimicrobial agents and chemotherapy - 1 Aug 2007

Korycka-Machala Malgorzata, Rychta Ewelina, Brzostek Anna, Sayer Heather R, Rumijowska-Galewicz Anna, Bowater Richard P, Dziadek Jarosław

Abstract excerpt

Mycobacteria contain genes for several DNA ligases, including ligA, which encodes a NAD(+)-dependent enzyme that has been postulated to be a target for novel antibacterial compounds. Using a homologous recombination system, direct evidence is presented that wild-type ligA cannot be deleted from the chromosome of Mycobacterium smegmatis. Deletions of native ligA in M. smegmatis could be obtained only after the...

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Identifiers

PMID: 17548501
DOI: 10.1128/AAC.00254-07
PMCID: PMC1932498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evaluation of NAD(+) -dependent DNA ligase of mycobacteria as a potential target for antibiotics.PMID 17548501Read ↗

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