Article
A mycobacterial smc null mutant is proficient in DNA repair and long-term survival.
Journal of bacteriology - 1 Jan 2008
Güthlein Carolin, Wanner Roger M, Sander Peter, Böttger Erik C, Springer Burkhard
Abstract excerpt
SMC (structural maintenance of chromosomes) proteins play fundamental roles in various aspects of chromosome organization and dynamics, including repair of DNA damage. Mutant strains of Mycobacterium smegmatis and Mycobacterium tuberculosis defective in SMC were constructed. Surprisingly, inactivation of smc did not result in recognizable phenotypes in hallmark assays characteristic for the function of these...
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