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Article

Specific and potent inhibition of NAD+-dependent DNA ligase by pyridochromanones.

The Journal of biological chemistry - 10 Oct 2003

Brötz-Oesterhelt Heike, Knezevic Igor, Bartel Stephan, Lampe Thomas, Warnecke-Eberz Ute, Ziegelbauer Karl, Häbich Dieter, Labischinski Harald

Abstract excerpt

Pyridochromanones were identified by high throughput screening as potent inhibitors of NAD+-dependent DNA ligase from Escherichia coli. Further characterization revealed that eubacterial DNA ligases from Gram-negative and Gram-positive sources were inhibited at nanomolar concentrations. In contrast, purified human DNA ligase I was not affected (IC50 > 75 microm), demonstrating remarkable specificity for the...

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PMID: 12867414
DOI: 10.1074/jbc.M306479200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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