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Article

Cloning and functional characterization of an NAD(+)-dependent DNA ligase from Staphylococcus aureus.

Journal of bacteriology - 1 May 2001

Kaczmarek F S, Zaniewski R P, Gootz T D, Danley D E, Mansour M N, Griffor M, Kamath A V, Cronan M, Mueller J, Sun D, Martin P K, Benton B, McDowell L, Biek D, Schmid M B

Abstract excerpt

A Staphylococcus aureus mutant conditionally defective in DNA ligase was identified by isolation of complementing plasmid clones that encode the S. aureus ligA gene. Orthologues of the putative S. aureus NAD(+)-dependent DNA ligase could be identified in the genomes of Bacillus stearothermophilus and other gram-positive bacteria and confirmed the presence of four conserved amino acid motifs, including motif I,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 11325928
DOI: 10.1128/JB.183.10.3016-3024.2001
PMCID: PMC95200

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Source receipt: pubmed, retrieved 7 Sept 2026.

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