Article
Low selection of preneoplastic hepatocytes after treatment with the 2-acetylaminofluorene diet-partial hepatectomy regimen in the liver of hepatocarcinogenesis-resistant DRH strain rats.
Oncology reports - 1 Jan 2007
Imai Koji, Yamamoto Masahiro, Tanaka Hiroki, Hashimoto Norikazu, Miyakoshi Masaaki, Honmou Satoshi, Yoshie Masumi, Tamakawa Susumu, Yaginuma Yuji, Kasai Shinichi, Ogawa Katsuhiro
Abstract excerpt
In hepatocarcinogenesis-resistant DRH rats, preneoplastic hepatocytic lesions are smaller than those of usual rats during carcinogenesis. When preneoplastic hepatocytes from DRH and Donryu (original strain of DRH) were reciprocally transplanted into the livers of DRH and Donryu treated with 2-acetylaminofluorene (2-AAF) diet/two-thirds hepatectomy (PH), the Donryu cells formed small colonies within the DRH liver,...
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