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Article

The role of jak2a in zebrafish hematopoiesis

2 Jun 2007

Abstract excerpt

Janus kinase 2 (Jak2) transduces signals from hematopoietic cytokines, and a gain-of-function mutation (Jak2(617V>F)) is associated with myeloproliferative diseases, particularly polycythemia vera. In this study, we examined the role of jak2a in zebrafish embryos in knock-down and overexpression studies using morpholinos (MOs) targeting the 5' untranslated region (UTR) (jak2a(UTR)-MO) and splice-site junction...

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Identifiers

PMID: 17545503
DOI: 10.1182/blood-2007-03-078287

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