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Article

A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera.

Experimental hematology - 1 Dec 2009

Ma Alvin C H, Fan August, Ward Alister C, Liongue Clifford, Lewis Rowena S, Cheng Suk H, Chan P K, Yip Sze-Fai, Liang Raymond, Leung Anskar Y H

Abstract excerpt

OBJECTIVE: The Janus kinase 2 (JAK2) is important for embryonic primitive hematopoiesis. A gain-of-function JAK2 (JAK2(V617F)) mutation in human is pathogenetically linked to polycythemia vera (PV). In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV. MATERIALS AND METHODS: Zebrafish...

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Source

Identifiers

PMID: 19772888
DOI: 10.1016/j.exphem.2009.08.008

Genes

JAK2

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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