Article
The unfolded protein response in hereditary haemochromatosis.
Journal of cellular and molecular medicine - 1 Apr 2008
de Almeida S F, de Sousa M
Abstract excerpt
To cope with the accumulation of unfolded or misfolded proteins the endoplasmic reticulum (ER) has evolved specific signalling pathways collectively called the unfolded protein response (UPR). Elucidation of the mechanisms governing ER stress signalling has linked this response to the regulation of diverse physiologic processes as well as to the progression of a number of diseases. Interest in hereditary...
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