Article
Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.
Nature cell biology - 1 Dec 2000
Ramalingam T S, West A P, Lebrón J A, Nangiana J S, Hogan T H, Enns C A, Bjorkman P J
Abstract excerpt
HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin receptor (TfR). Here we show that wild-type HFE and TfR localize in endosomes and at the basolateral membrane of a polarized duodenal epithelial cell line, whereas the primary haemochromatosis HFE mutant, and another mutant with impaired TfR-binding ability accumulate in the ER/Golgi and at the basolateral membrane,...
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