Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.

doi:10.1038/35046611

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Article

Binding to the transferrin receptor is required for endocytosis of HFE and regulation of iron homeostasis.

Nature cell biology - 1 Dec 2000

Ramalingam T S, West A P, Lebrón J A, Nangiana J S, Hogan T H, Enns C A, Bjorkman P J

This publication is marked as retracted by the source.

Abstract excerpt

HFE, the protein that is mutated in hereditary haemochromatosis, binds to the transferrin receptor (TfR). Here we show that wild-type HFE and TfR localize in endosomes and at the basolateral membrane of a polarized duodenal epithelial cell line, whereas the primary haemochromatosis HFE mutant, and another mutant with impaired TfR-binding ability accumulate in the ER/Golgi and at the basolateral membrane,...

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Identifiers

PMID: 11146662
DOI: 10.1038/35046611

Genes

HFE
LDLR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.