The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame.

doi:10.1093/nar/19.23.6441

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame.

Nucleic acids research - 11 Dec 1991

Leegwater P A, Strating M, Murphy N B, Kooy R F, van der Vliet P C, Overdulve J P

Abstract excerpt

As an initial step towards the characterization of replicative DNA polymerases of trypanosomes, we have cloned, sequenced and examined the expression of the Trypanosoma (Trypanozoon) brucei brucei gene that encodes the DNA polymerase alpha catalytic core (pol alpha). The protein sequence contains the six conserved regions that have been recognized previously in eukaryotic and viral replicative DNA polymerases. In...

Topics

Amino Acid Sequence
Animals
Base Sequence
Blotting, Southern
Cloning, Molecular
DNA Polymerase II
DNA, Protozoan
Gene Expression Regulation, Enzymologic
Genetic Linkage
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Molecular Sequence Data

Open Reading Frames

Restriction Mapping

Sequence Alignment

Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 1754381
DOI: 10.1093/nar/19.23.6441
PMCID: PMC329194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1754381-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Trypanosoma brucei DNA polymerase alpha core subunit gene is developmentally regulated and linked to a constitutively expressed open reading frame.PMID 1754381Read ↗

The Transcriptome of the Human Pathogen Trypanosoma brucei at Single-Nucleotide ResolutionSemantic proximity Read ↗

Functional Characterization of a Trypanosoma brucei TATA-Binding Protein-Related Factor Points to a Universal Regulator of Transcription in TrypanosomesSemantic proximity Read ↗

The epigenome of Trypanosoma brucei: A regulatory interface to an unconventional transcriptional machineSemantic proximity Read ↗

Beyond the transcript: chromatin implications in trans-splicing in TrypanosomatidsSemantic proximity Read ↗

Transcriptionally active TFIIH of the early-diverged eukaryote Trypanosoma brucei harbors two novel core subunits but not a cyclin-activating kinase complexSemantic proximity Read ↗

Unexpected diversity in eukaryotic transcription revealed by the retrotransposon hotspot family of Trypanosoma bruceiSemantic proximity Read ↗

DNA polymerase kappa from <i>Trypanosoma cruzi</i> localizes to the mitochondria, bypasses 8‐oxoguanine lesions and performs DNA synthesis in a recombination intermediateSemantic proximity Read ↗

Gene Expression in Trypanosomatid ParasitesSemantic proximity Read ↗

TbISWI regulates multiple polymerase I (Pol I)-transcribed loci and is present at Pol II transcription boundaries in Trypanosoma brucei.Semantic proximity Read ↗

Open chromatin analysis in Trypanosoma cruzi life forms highlights critical differences in genomic compartments and developmental regulation at tDNA lociSemantic proximity Read ↗

TRANSCRIPTION OF PROTEIN- CODING GENES IN TRYPANOSOMES BY RNA POLYMERASE ISemantic proximity Read ↗

Chromatin remodelling during the life cycle of trypanosomatids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.