DNA polymerase kappa from <i>Trypanosoma cruzi</i> localizes to the mitochondria, bypasses 8‐oxoguanine lesions and performs DNA synthesis in a recombination intermediate

Abstract excerpt

DNA polymerase kappa (Pol kappa) is a low-fidelity polymerase that has the ability to bypass several types of lesions. The biological role of this enzyme, a member of the DinB subfamily of Y-family DNA polymerases, has remained elusive. In this report, we studied one of the two copies of Pol kappa from the protozoan Trypanosoma cruzi (TcPol kappa). The role of this TcPol kappa copy was investigated by analysing...