Article
Sequence space and the ongoing expansion of the protein universe.
Nature - 17 Jun 2010
Povolotskaya Inna S, Kondrashov Fyodor A
Abstract excerpt
The need to maintain the structural and functional integrity of an evolving protein severely restricts the repertoire of acceptable amino-acid substitutions. However, it is not known whether these restrictions impose a global limit on how far homologous protein sequences can diverge from each other. Here we explore the limits of protein evolution using sequence divergence data. We formulate a computational...
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