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Article

A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.

Genes, chromosomes & cancer - 1 Sept 2007

Poland Kathryn S, Azim Mohammed, Folsom Matthew, Goldfarb Richard, Naeem Rizwan, Korch Christopher, Drabkin Harry A, Gemmill Robert M, Plon Sharon E

Abstract excerpt

Studying the molecular basis of familial renal cell carcinoma (RCC) has allowed identification of novel RCC genes involved in the pathogenesis of both inherited and sporadic RCC. We describe a constitutional balanced t(3;8)(p14;q24.1) translocation found in a brother and sister with bilateral cle...

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Share to Acid Anhydride Hydrolases
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Artificial, Bacterial

Share to Chromosomes, Human, Pair 3

Share to Chromosomes, Human, Pair 8

Share to Kidney Neoplasms

Share to Translocation, Genetic

Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

Identifiers

PMID: 17539022
DOI: 10.1002/gcc.20466

Genes

FHIT
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17539022-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma.PMID 17539022Read ↗

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