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Article

The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma.

Molecular cancer - 30 Jul 2009

Gimelli Stefania, Beri Silvana, Drabkin Harry A, Gambini Claudio, Gregorio Andrea, Fiorio Patrizia, Zuffardi Orsetta, Gemmill Robert M, Giorda Roberto, Gimelli Giorgio

Abstract excerpt

BACKGROUND: RNF139/TRC8 is a potential tumor suppressor gene with similarity to PTCH, a tumor suppressor implicated in basal cell carcinomas and glioblastomas. TRC8 has the potential to act in a novel regulatory relationship linking the cholesterol/lipid biosynthetic pathway with cellular growth...

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Share to Chromosomes, Human, Pair 22
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Von Hippel-Lindau Tumor Suppressor Protein

Source

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Identifiers

PMID: 19642973
DOI: 10.1186/1476-4598-8-52
PMCID: PMC2727492

Genes

TSN
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19642973-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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