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Article

Disruption of a novel MFS transporter gene, DIRC2, by a familial renal cell carcinoma-associated t(2;3)(q35;q21).

Human molecular genetics - 15 Mar 2002

Bodmer Daniëlle, Eleveld Marc, Kater-Baats Ellen, Janssen Irene, Janssen Bert, Weterman Marian, Schoenmakers Eric, Nickerson Michael, Linehan Marston, Zbar Berton, van Kessel Ad Geurts

Abstract excerpt

Previously, we described a family with a significantly increased predisposition for renal cell cancer co-segregating with a t(2;3)(q35;q21) chromosomal translocation. Several primary tumors of the clear cell type from different family members were analyzed at a molecular level. Loss of the derivative chromosome 3 was consistently found. In addition, different somatic Von Hippel Lindau (VHL) gene mutations were...

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Share to Carcinoma, Renal Cell
Share to Chromosomes, Human, Pair 2

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Kidney Tubules, Proximal

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Source

Identifiers

PMID: 11912179
DOI: 10.1093/hmg/11.6.641

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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