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Article

Understanding familial and non-familial renal cell cancer

27 Sept 2002

Abstract excerpt

Molecular genetic analysis of familial and non-familial cases of conventional renal cell carcinoma (RCC) revealed a critical role(s) for multiple genes on human chromosome 3. For some of these genes, e.g. VHL, such a role has been firmly established, whereas for others, definite confirmation is still pending. Additionally, a novel role for constitutional chromosome 3 translocations as risk factors for...

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PMID: 12351585
DOI: 10.1093/hmg/11.20.2489

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