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Article

Genomic Heterogeneity of Translocation Renal Cell Carcinoma

1 Jul 2013

Abstract excerpt

PURPOSE: Translocation renal cell carcinoma (tRCC) is a rare subtype of kidney cancer involving the TFEB/TFE3 genes. We aimed to investigate the genomic and epigenetic features of this entity. EXPERIMENTAL DESIGN: Cytogenomic analysis was conducted with 250K single-nucleotide polymorphism microarrays on 16 tumor specimens and four cell lines. LINE-1 methylation, a surrogate marker of DNA methylation, was...

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PMID: 23817689
DOI: 10.1158/1078-0432.ccr-12-3825

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