Article
Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort.
Inflammatory bowel diseases - 1 Oct 2007
Gearry Richard B, Roberts Rebecca L, Burt Michael J, Frampton Chris M A, Chapman Bruce A, Collett Judith A, Shirley Philippa, Allington Melanie D E, Kennedy Martin A, Barclay Murray L
Abstract excerpt
BACKGROUND: NOD2 mutations are associated with Crohn's disease (CD) in Caucasian clinic-based cohorts. Data from population-based cohorts are limited. Clinic-based studies may overestimate this association. Genotype-phenotype relationships are yet to be assessed using the Montreal classification. We hypothesized that the NOD2-CD association would be weaker in a population-based cohort, and that the Montreal...
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