Article
The Engrailed homeobox genes determine the different foliation patterns in the vermis and hemispheres of the mammalian cerebellum.
Development (Cambridge, England) - 1 Feb 2010
Cheng Yulan, Sudarov Anamaria, Szulc Kamila U, Sgaier Sema K, Stephen Daniel, Turnbull Daniel H, Joyner Alexandra L
Abstract excerpt
Little is known about the genetic pathways and cellular processes responsible for regional differences in cerebellum foliation, which interestingly are accompanied by regionally distinct afferent circuitry. We have identified the Engrailed (En) homeobox genes as being crucial to producing the distinct medial vermis and lateral hemisphere foliation patterns in mammalian cerebella. By producing a series of temporal...
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