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Article

Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.

The Journal of biological chemistry - 14 Oct 2005

Sasaki Carl Y, Barberi Theresa J, Ghosh Paritosh, Longo Dan L

Abstract excerpt

The association of the NF-kappaB p65/p50 dimer with IkappaBalpha plays a pivotal role in regulating its nuclear translocation and gene transcription. In addition, serine phosphorylation at various sites of the p65 subunit has been shown to be important in initiating transcription. Here we demonstrate that the regulation of nuclear translocation of p65 phosphorylated at serine 536 is not dependent on IkappaBalpha....

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Source

Identifiers

PMID: 16105840
DOI: 10.1074/jbc.M504943200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of RelA/p65 on serine 536 defines an I{kappa}B{alpha}-independent NF-{kappa}B pathway.PMID 16105840Read ↗

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.Semantic proximity Read ↗

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.Semantic proximity Read ↗

Suppression of p65 phosphorylation coincides with inhibition of IkappaBalpha polyubiquitination and degradation.Semantic proximity Read ↗

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.Semantic proximity Read ↗

Hypo-phosphorylation leads to nuclear retention of NF-kappaB p65 due to impaired IkappaBalpha gene synthesis.Semantic proximity Read ↗

IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.Semantic proximity Read ↗

Phosphorylation of serine 468 by GSK-3beta negatively regulates basal p65 NF-kappaB activity.Semantic proximity Read ↗

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells.Semantic proximity Read ↗

Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.Semantic proximity Read ↗

Promoter-dependent effect of IKKalpha on NF-kappaB/p65 DNA binding.Semantic proximity Read ↗

Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.Semantic proximity Read ↗

A phosphomimetic mutant of RelA/p65 at Ser536 induces apoptosis and senescence: An implication for tumor-suppressive role of Ser536 phosphorylation.Semantic proximity Read ↗

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