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Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature

21 Oct 2009

Abstract excerpt

OBJECTIVE: The human aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 genes encoding enzymes critical for NAD(P)-dependent oxidation of endogenous and exogenous aldehydes, including drugs and environmental toxicants. Mutations in ALDH genes are the molecular basis of several disease states (e.g. Sjögren-Larsson syndrome, pyridoxine-dependent seizures, and type II hyperprolinemia) and may contribute...

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PMID: 19823103
DOI: 10.1097/fpc.0b013e3283329023

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