Article
N-Acetyltransferase (NAT) 2 acetylator status and age of tumour onset in patients with sporadic and familial, microsatellite stable (MSS) colorectal cancer.
International journal of colorectal disease - 1 Feb 2007
Pistorius Steffen, Goergens Heike, Engel Christoph, Plaschke Jens, Krueger Stefan, Hoehl Ruth, Saeger Hans-Detlev, Schackert Hans K
Abstract excerpt
INTRODUCTION: N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens. Allelic variants of the NAT2 gene are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes and causing the individual differences in the NAT2 metabolic capacity. To clarify...
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