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Article

Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.

Biochimica et biophysica acta - 1 Jul 2007

Chen Mengqian, Fu Ya-Yuan, Lin Chen-Yong, Chen Li-Mei, Chai Karl X

Abstract excerpt

Expression of prostasin in the PC-3 human prostate carcinoma cells inhibited in vitro invasion, but the molecular mechanisms are unknown. Wild-type human prostasin or a serine active-site mutant prostasin was expressed in the PC-3 cells. Molecular changes were measured at the mRNA and the protein levels. Cell signaling changes were evaluated by measuring phosphorylation of the extracellular signal-regulated...

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Identifiers

PMID: 17532063
DOI: 10.1016/j.bbamcr.2007.04.013
PMCID: PMC1950849

Genes

EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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