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Article

Loss of Speckle-Type POZ Protein Promotes Prostate Cancer Cell Migration and Invasion Through Upregulation of MCP-1.

Medical science monitor : international medical journal of experimental and clinical research - 19 Apr 2021

Shi Junlin, Cao Ji, Lu Xiaomei, Fan Langlin, Guo Hongwei, Fu Jiejun

Abstract excerpt

BACKGROUND The goal of this study is to verify that the loss of speckle-type POZ protein (SPOP) promotes the migration and invasion of prostate cancer cells, and that this process is brought about by an increase in MCP-1. MATERIAL AND METHODS SPOP knockout C4-2 cells (C4-2 SPOP-/-) were verified by western blotting. Transwell and wound-healing assays were applied to verify different migration and invasion...

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Identifiers

PMID: 33872295
DOI: 10.12659/MSM.929199
PMCID: PMC8063634

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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