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Article

Identification of sequences that target BRCA1 to nuclear foci following alkylative DNA damage.

Cellular signalling - 1 Sept 2007

Au Wendy W Y, Henderson Beric R

Abstract excerpt

BRCA1 is a tumor suppressor involved in the maintenance of genome integrity. BRCA1 co-localizes with DNA repair proteins at nuclear foci in response to DNA double-strand breaks caused by ionizing radiation (IR). The response of BRCA1 to agents that elicit DNA single-strand breaks (SSB) is poorly defined. In this study, we compared chemicals that induce SSB repair and observed the most striking nuclear...

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Topics

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Share to Alkylating Agents
Share to Ataxia Telangiectasia Mutated Proteins
Share to BRCA1 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyl Methanesulfonate

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Share to Protein Transport

Share to Radiation, Ionizing

Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 17531442
DOI: 10.1016/j.cellsig.2007.04.010

Genes

BRCA1
SSB
XRCC1
BARD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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