Article
Association of ionizing radiation-induced foci of NBS1 with chromosomal instability and breast cancer susceptibility.
Radiation research - 1 Oct 2006
Someya Masanori, Sakata Koh-ichi, Tauchi Hiroshi, Matsumoto Yoshihisa, Nakamura Asako, Komatsu Kenshi, Hareyama Masato
Abstract excerpt
NBS1, a protein essential for DNA double-strand break repair, relocalizes into subnuclear structures upon induction of DNA damage by ionizing radiation, forming ionizing radiation-induced foci. We compared radiation-induced NBS1 foci in peripheral blood lymphocytes (PBLs) from 46 sporadic breast cancer patients and 30 healthy cancer-free volunteers. The number of persistent radiation-induced NBS1 foci per nucleus...
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