Article
Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis.
Neuroscience letters - 13 Jun 2007
Coppedè Fabio, Mancuso Michelangelo, Lo Gerfo Annalisa, Carlesi Cecilia, Piazza Selina, Rocchi Anna, Petrozzi Lucia, Nesti Claudia, Micheli Dario, Bacci Andrea, Migliore Lucia, Murri Luigi, Siciliano Gabriele
Abstract excerpt
Amyotropic lateral sclerosis (ALS) is a fatal and progressive neurodegenerative disease causing the loss of motoneurons of the brain and the spinal cord. The etiology of ALS is still uncertain, but males are at increased risk for the disease than females. Several studies have suggested that motoneurons in ALS might be subjected to the double insult of increased DNA oxidative damage and deficiencies in DNA repair...
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