Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.

Current biology : CB - 19 Mar 2002

Simoncic Paul D, Lee-Loy Ailsa, Barber Dwayne L, Tremblay Michel L, McGlade C Jane

Abstract excerpt

BACKGROUND: The immune response is regulated through a tightly controlled cytokine network. The counteracting balance between protein tyrosine kinase (PTK) and protein tyrosine phosphatase (PTP) activity regulates intracellular signaling in the immune system initiated by these extracellular polypeptides. Mice deficient for the T cell protein tyrosine phosphatase (TCPTP) display gross defects in the hematopoietic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Interleukin-2
Share to Janus Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 3

Share to Nitric Oxide Synthase

Share to Nitric Oxide Synthase Type II

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 2

Share to STAT1 Transcription Factor

Source

Identifiers

PMID: 11909529
DOI: 10.1016/s0960-9822(02)00697-8

Genes

JAK1
JAK3
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3.PMID 11909529Read ↗

Regulation of T cell homeostasis by JAKs and STATsSemantic proximity Read ↗

Janus kinases in immune cell signalingSemantic proximity Read ↗

Janus kinase 3: the controller and the controlled.Semantic proximity Read ↗

Tyrosine kinase 2 (TYK2) in cytokine signalling and host immunitySemantic proximity Read ↗

Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation.Semantic proximity Read ↗

Defective lymphoid development in mice lacking Jak3.Semantic proximity Read ↗

TULA‐family proteins: A new class of cellular regulatorsSemantic proximity Read ↗

A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity.Semantic proximity Read ↗

TYK2 kinase activity is required for functional type I interferon responses in vivo.Semantic proximity Read ↗

Severe defects in immunity and hematopoiesis caused by SHP-1 protein-tyrosine-phosphatase deficiency.Semantic proximity Read ↗

Involvement of the protein tyrosine phosphatase PTP1C in cellular physiology, autoimmunity and oncogenesis.Semantic proximity Read ↗

Peripheral expression of Jak3 is required to maintain T lymphocyte function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.