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Article

Cell cycle analysis and DNA aneuploidy in autoimmune mice homozygous for the lpr and gld mutations.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1991

Prasad V S, Sidman C L

Abstract excerpt

Homozygosity for either of the mutations lpr (lymphoproliferation) or gld (generalized lymphoproliferative disease) in mice results in lymphoproliferation and autoimmune disease. To investigate the site and time of excessive lymphocyte proliferation in these mice, cell nuclei of normal and mutant mice of various ages were stained with propidium iodide and DNA profiles were analyzed by flow cytometry. Two major...

Topics

Aneuploidy
Animals
Antigens, Surface
Autoimmunity
Cell Cycle
Cell Division
DNA
Heterozygote
Homozygote
Lymphoma
Lymphoproliferative Disorders
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Mutation

Organ Specificity

Source

Identifiers

PMID: 1753097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1753097-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Cell cycle analysis and DNA aneuploidy in autoimmune mice homozygous for the lpr and gld mutations.PMID 1753097Read ↗

The proliferative in vivo activities of lpr double-negative T cells and the primary role of p59fyn in their activation and expansionSemantic proximity Read ↗

<i>Lpr</i> and <i>gld</i>: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative DiseaseSemantic proximity Read ↗

Genotype-restricted lymphoproliferation in autoimmune lpr mice.Semantic proximity Read ↗

lpr And gld: Single Gene Models Of Systemic Autoimmunity And Lymphoproliferative DiseaseSemantic proximity Read ↗

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice.Semantic proximity Read ↗

The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation.Semantic proximity Read ↗

Lymphadenopathy induced by the cooperation between lprcg and gld genes is of lpr but not of gld phenotype.Semantic proximity Read ↗

Haematopoietic cell transfers between C57BL/6 mice differing at the lpr or gld locus.Semantic proximity Read ↗

Liver is a possible site for the proliferation of abnormal CD3+4-8- double-negative lymphocytes in autoimmune MRL-lpr/lpr mice.Semantic proximity Read ↗

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