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Article

Endogenous endostatin inhibits choroidal neovascularization

25 May 2007

Abstract excerpt

Endostatin, a fragment of the basement membrane component collagen XVIII, exhibits antiangiogenic properties in vitro and in vivo when high doses are administered. It is not known whether endogenous endostatin at physiological levels has a protective role as an inhibitor of pathological angiogenesis, such as choroidal neovascularization (CNV) in age-related macular degeneration. Using a laser injury model, we...

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PMID: 17526870
DOI: 10.1096/fj.07-8422com

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