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An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression

5 Oct 2020

Abstract excerpt

During the progression of ocular diseases such as retinopathy of prematurity and diabetic retinopathy, overgrowth of retinal blood vessels results in the formation of pathological neovascular tufts that impair vision. Current therapeutic options for treating these diseases include antiangiogenic strategies that can lead to the undesirable inhibition of normal vascular development. Therefore, strategies that...

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PMID: 33020273
DOI: 10.1073/pnas.2015980117

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