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Article

Anti-angiogenic effects of a mutant endostatin: a new prospect for treating retinal and choroidal neovascularization.

PloS one - 1 Jan 2014

Bai Yujing, Zhao Min, Zhang Chunfang, Li Shanshan, Qi Yun, Wang Bin, Huang Lvzhen, Li Xiaoxin

Abstract excerpt

PURPOSE: Pathological fundus angiogenesis is a major cause of vision loss in retina diseases. Endostatin, a C-terminal fragment of collagen XVIII, is an endogenous anti-angiogenic protein. The present study aimed to investigate the in vitro and in vivo anti-angiogenic properties of two proteins: an N-terminal H1D/H3D mutant endostatin (M-ES) and a polyethylene glycol propionaldehyde (PEG) covalent M-ES...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25380141
DOI: 10.1371/journal.pone.0112448
PMCID: PMC4224489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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