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Engineered virus-like particle-assembled VEGF-targeting Cas9 ribonucleoprotein treatment alleviates neovascularization in wet age-related macular degeneration

2025-02-07

Abstract excerpt

<title>Abstract</title> <p>Background Age-related macular degeneration (AMD), particularly the wet form, is a leading cause of vision loss, characterized by abnormal blood vessel growth in the retina. Targeting vascular endothelial growth factor (VEGF) has proven effective in mitigating the disease. While knock-out VEGF expression using genome editing is a proven therapeutic strategy, conventional delivery syste...

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Literature Corpus work: ecc7c0a9-71bc-58b2-a2a6-530c4c1cbd80
DOI: 10.21203/rs.3.rs-5961928/v1

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